Organic syntheses. Volume 38

Hydroxynitrile Lyases, Interesting Biocatalysts in Stereoselective Organic Syntheses

Hydroxynitrile lyases (HNLs) from Prunus amygdalus (PaHNL), Sorghum bicolor (SbHNL), Manihot esculenta (MeHNL) and Hevea brasiliensis (HbHNL) are excellent biocatalysts for the preparation of optically active cyanohydrins. (R)as well as (S)-cyanohydrins are obtained in high optical and chemical yields. The synthetic potential of the now easily available optically pure cyanohydrins is demonstrat...

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Syntheses, structural studies, and magnetic properties of divalent Cu and Co selenites with organic constituents.

Six new divalent metal selenites have been synthesized by hydro-/solvothermal methods which leads to the incorporation of the organic template as a cation or a ligand. The structure of [H(2)pip][Cu(SeO(3))(2)] (1) (pip=piperazine) features 1D anionic chains of [Cu(SeO(3))(2)](2-) which are cross-linked by the template cations through hydrogen bonds into a 2D layer. In [Cu(C(3)H(4)N(2))(SeO(3))]...

Total syntheses of colchicine in comparison: a journey through 50 years of synthetic organic chemistry.

Colchicine, the major alkaloid of the meadow saffron, is one of the most prominent natural products and, like other tubulin-binding natural products (e.g. taxol and the epothilones), exhibits great pharmaceutical potential. The first syntheses in the late 1950s were milestones in natural product synthesis. But even today this structurally supposedly simple molecule poses a challenge to syntheti...

Microporous metal-organic frameworks incorporating 1,4-benzeneditetrazolate: syntheses, structures, and hydrogen storage properties.

The potential of tetrazolate-based ligands for forming metal-organic frameworks of utility in hydrogen storage is demonstrated with the use of 1,4-benzeneditetrazolate (BDT(2)(-)) to generate a series of robust, microporous materials. Reaction of H(2)BDT with MnCl(2).4H(2)O and Mn(NO(3))(2).4H(2)O in N,N-diethylformamide (DEF) produces the two-dimensional framework solids Mn(3)(BDT)(2)Cl(2)(DEF...